![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
Extracts of celery (Apium graveolens. L.; Apiaceae) leaves prepared in solvents of different polarity, viz., ether, chloroform, ethyl acetate, n.-butanol, and water, were used to study their antipyretic effect in mice. Experiments were conducted on white laboratory mice divided into five groups. On the first day of the experiment, their rectal temperatures were measured every 30 min during 5 h (basal temperature). On the second day, the animals were given 12% yeast suspension to induce a pyrogenic effect and on the third day the same dose of yeast and the appropriate celery extract, and the rectal temperatures were measured in the same way as basal temperature. By plotting the measured temperatures versus time, the corresponding areas-under-the-curve (AUC) were obtained for each group of animals. The AUC values were used to determine statistically significant differences between them. The results showed that extracts of celery leaf decreased (annuled) the pyrogenic effect of 12% yeast suspension.