Antinociceptive and Anti-inflammatory Activities of Ballota inaequidens.

Abstract

The water extract of Ballota inaequidens. Hub.-Mor. & Patzak (Lamiaceae) was investigated for antinociceptive and anti-inflammatory activities in mice and rats. The tail-flick test, acetic acid–induced writhing test, and the carrageenan-induced rat paw edema test were used to determine these effects. Our findings show that Ballota inaequidens. caused dose-related inhibition in the acetic acid–induced abdominal stretching in mice. The medium effective dose (ED₅₀) value of Ballota inaequidens. was found to be 85.38 mg/kg. Ballota inaequidens. showed no significant changes in the nociceptive threshold of the tail-flick test but did show an inhibition of paw edema induced by carrageenan. The ED₅₀ value of Ballota inaequidens. was found to be 99.42 mg/kg. The current study reveals that the water extract of Ballota inaequidens. possesses promising antinociceptive and anti-inflammatory activities.

Keywords:

• Anti-inflammatory activity
• antinociceptive activity
• Ballota inaequidens
• median lethal dose (LD₅₀)