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Abstract
The in vitro. venom neutralizing capacity of tannic acid against the activities of Naja kaouthia. (Naja naja kaouthia. Lesson [Elapidae]) venom was investigated. Tannic acid was found to be effective in neutralizing the activities of Naja kaouthia. (NK) venom. The lethal effect of four-times the LD50 in mice and the necrotizing effect of one minimum necrotizing dose (1 MND) in rats of NK venom were fully inhibited by tannic acid at ≥ 431 µg/mouse, with the median effective dose (ED50) of 334 µg/mouse and ≥ 30 µg/rat, respectively. The acetylcholinesterase activity of NK venom was almost completely neutralized (≥ 99%) by tannic acid at ≥ 1% w/v. It was evident that tannic acid was nontoxic and did not cause either a lethal effect in mice (at its maximum tested dose of 845 µg/mouse) or necrotic lesions in rats (at doses between 7.5 and 60 µg/rat).