Cytotoxic Activity of Some Anatolian Salvia. Extracts and Isolated Abietane Diterpenoids

Abstract

Salvia hypargeia. Fisch. et Mey. (Lamiaceae) root extract, among 16 Salvia. extracts, showed the highest activity against the human ovarian cancer cell line. Bioactivity-guided fractionation of this plant extract has yielded four abietane-type diterpenes [5,6-didehydro-7-hydroxytaxodone (1), 14-deoxycoleon U (= 6-hydroxysalvinolone) (2), demethylcryptojaponol (3), and salvicanaric acid (4)] two triterpenes (lupeol and lupeol-3-acetate), and a fatty acid mixture consisting mainly of palmitic acid (51.6%) and palmitoleic acid (6.4%). Compounds 2 and 3 were found to be active against A2780 human ovarian cancer cell line with IC₅₀ values of 3.9 and 1.2 μ g/mL, respectively, and the fatty acid composition was the most active part of the extract (IC₅₀ = 0.6 μ g/mL).

Keywords:

• Abietane diterpenes
• cytotoxic activity
• Lamiaceae
• Salvia. extracts
• Salvia hypargeia

Notes

*The structure of 6-hydroxysalvinolone was incorrectly drawn without a keto group at C-7 in the paper.