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Abstract
The acetic acid–induced abdominal writhing, the tail flick, and the croton oil–induced mouse ear edema tests were used to study the anti-inflammatory effects of the aqueous extract from Lafoensia pacari. A. St.-Hil. (Lythraceae) stem bark. Pentobarbital-induced sleeping time was used to study the central nervous system depressant effect of the extract. The aqueous extract caused a dose-dependent inhibition of acetic acid–induced abdominal writhing and ear edema formation and produced a significant (p < 0.05) dose-related increase in the duration of sleep. The results suggest that Lafoensia pacari. stem bark contains compounds with anti-inflammatory, analgesic, and central depressant actions.