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Abstract
Persea macrantha (Nees) Kosterm (Lauraceae) is a traditional medicinal plant being used in the treatment of asthma and rheumatism. The present study evaluated the anti-inflammatory and anti-arthritic properties of different extracts of stem bark of Persea macrantha in rats. Anti-inflammatory activity was determined in albino rats in a model of acute plantar inflammation induced by carrageenan, while the serial extracts were tested for anti-arthritic activity in adjuvant-induced arthritis in rats. The petroleum ether extract (PE) and aqueous extract (AE) caused a significant inhibition (43.90% and 39.02%, respectively) of the carrageenan-induced paw edema at a dose of 200 mg/kg, when compared with control and reference drug, diclofenac. PE (200 mg/kg) significantly decreased primary lesions (30.95%), secondary lesions (37.14%) and total radiological score (6.33 ± 0.42) in adjuvant induced arthritis. The findings of this experimental animal study indicate anti-inflammatory and anti-arthritic properties of Persea macrantha and thus provide pharmacological support to the traditional use of Persea macrantha in the treatment and management of painful, arthritic inflammatory conditions.
Acknowledgements
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.