Analgesic activity of extracts of Kyllinga monocephala

Abstract

The analgesic activity of the methanol extract of the leaves of Kyllinga monocephala Rottb. (Cyperaceae) was evaluated using the acetic acid-induced writhing test on mice and was found to significantly reduce the number of writhes in mice by half. Following a bioassay-guided fractionation scheme, statistically significant analgesic activity was observed with both the hexane and ethyl acetate partitions. An active fraction was identified after fractionation of the hexane extract, whereas two active fractions were identified after fractionation of the ethyl acetate extract. This is the first report of the analgesic activity of K. monocephala.

Keywords::

• Kyllinga monocephala
• analgesic activity
• acetic acid-induced writhing test
• bioassay-guided fractionation

Declaration of interest: E.C. Amor is grateful to the Natural Sciences Research Institute of the College of Science, UP Diliman, Quezon City for the funding support. The authors alone are responsible for the content and writing of the paper.