Anti-inflammatory activity of roots of Achyranthes aspera

Abstract

This study investigated the anti-inflammatory potential of the alcohol extract of Achyranthes aspera Linn. (Amaranthaceae) in Wistar rats after oral administration (50, 100, and 200 mg/kg). This was done using the carrageenan-induced paw edema method (acute inflammatory model) and cotton pellet granuloma test (chronic inflammatory model). The alcohol extract showed significant suppressed granuloma formation. Collectively, these data demonstrate promising anti-inflammatory activity against both acute and chronic inflammation. In addition, inhibition of prostaglandins and bradykinins may play a role. This study revealing the promising anti-inflammatory activity of Achyranthes aspera roots has been carried out scientifically for the first time.

Keywords::

• Alcohol extract
• Achyranthes aspera (Amaranthaceae)
• anti-inflammatory activity
• roots

Acknowledgements

The authors are grateful to the Head, School of Pharmacy, INTI International University College and the Principal, K.M. College of Pharmacy, for providing the laboratory facilities to enable this research to be carried out.

Declaration of interest: The authors report no conflicts of interest.