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Abstract
Objectives. Studies have shown that fasting blood glucose (FBG) is closely associated with poor prognosis in patients with coronary heart disease (CHD) after percutaneous coronary intervention (PCI), but its association with in-stent restenosis (ISR) is still unclear. Therefore, this study was to explore the association between FBG with ISR in patients with CHD after PCI. Design. In this cohort study, we included 531 patients with CHD who underwent PCI. Logistic regression, receiver operating characteristic (ROC), subgroup analysis and restricted cubic spline (RCS) were used to assess the association between FBG with ISR. Results. A total of 124 (23.4%) patients had ISR. Patients with higher levels of FBG had higher incidence of ISR compared to those with lower levels of FBG (p = 0.002). In multivariable logistic regression analyses, higher levels of FBG remained strongly associated with higher risk of ISR (as a categorical variable, OR: 1.89, 95% CI: 1.21–2.94, p = 0.005; as a continuous variable, OR: 1.12, 95% CI: 1.03–1.23, p = 0.011). ROC analysis also showed that FBG might be associated with the occurrence of ISR (AUC = 0.577, 95% CI: 0.52–0.64, p = 0.013). Subgroup analyses showed the association of FBG with ISR was also stable in several subgroups (< 60 years or ≥ 60 years, male, with or without smoking, without diabetes and without hypertension). And RCS analysis showed that FBG was linearly and positively associated with the risk of ISR. Conclusions. Higher levels of FBG were closely associated with higher risk of ISR in patients with CHD after PCI.
Acknowledgments
We would like to thank all the patients, nurses, doctors and researchers who participated in the original study for their valuable contributions.
Ethical approval and consent to participate
The original study protocol was approved by the Ethics Committee of the First affiliated Hospital of Zhengzhou University and complied with the Declaration of Helsinki. And informed consent was waived for all patients due to the nature of the retrospective study by the Ethics Committee of the First affiliated Hospital of Zhengzhou University.
Consent for publication
Not Applicable.
Authors’ contributions
Ge-cai Chen, Xu Huang, Zhong-bao Ruan, Li Zhu, Mei-xiang Wang and Yi Lu: Writing - review & editing. Ge-cai Chen: Data curation, Writing - original draft. Ge-cai Chen: Conceptualization, Methodology, Software. Cheng-chun Tang: Conceptualization, Funding acquisition, Project administration, Supervision. All authors read and approved the final manuscript.
Disclosure statement
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Data availability statement
The datasets used/or analyzed during the current study are available from the corresponding author on reasonable request or the Dryad Digital Repository.