Sinus bradycardia after intravenous pulse methylprednisolone therapy in patients with systemic lupus erythematosus

Miho OhshimaDepartment of Allergy and Rheumatology, University of Tokyo, Tokyo, Japan; ;Department of Rheumatic Diseases, Tama-Hokubu Medical Center, Health and Medical Treatment Corporation, Tokyo, Japan; Correspondence[email protected]

Kimito KawahataDepartment of Allergy and Rheumatology, University of Tokyo, Tokyo, Japan; ;Department of Rheumatology, Tokyo Medical and Dental University, Tokyo, Japan;

Hiroko KandaDepartment of Allergy and Rheumatology, University of Tokyo, Tokyo, Japan; ;Department of Immunotherapy Management, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

Kazuhiko YamamotoDepartment of Allergy and Rheumatology, University of Tokyo, Tokyo, Japan;

Abstract

Sinus bradycardia is reported as an adverse effect of high-dose glucocorticoid therapy. We report three cases of systemic lupus erythematosus, wherein intravenous pulse methylprednisolone was administered. The patients’ average baseline heart rate was 72 beats/min, which decreased 30% from baseline at 61 h after beginning the therapy. The average minimum heart rate was 38 beats/min, and this rate continued for 169 h on average. No other causes for bradycardia were found, suggesting that the administration of glucocorticoid pulse therapy resulted in decreased heart rate.

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Sinus bradycardia after intravenous pulse methylprednisolone therapy in patients with systemic lupus erythematosus

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Sinus bradycardia after intravenous pulse methylprednisolone therapy in patients with systemic lupus erythematosus

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