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Modern Rheumatology Volume 29, 2019 - Issue 4
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Case Report

Successful adalimumab treatment and usefulness of capsule endoscopy for gut inflammation concomitant with ankylosing spondylitis

Shinji OtaDepartment of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; View further author information
,
Hirotake SakurabaDepartment of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; ;Department of Community Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; Correspondence[email protected]
View further author information
,
Hiroto HiragaDepartment of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; ;Department of Community Healthcare Development in Odate and North Akita, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; View further author information
,
Keisuke HasuiDepartment of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; View further author information
,
Miwa SatakeDepartment of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; View further author information
,
Norihiro HanabataDepartment of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; View further author information
,
Yui AkemotoDepartment of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; View further author information
,
Rina WatanabeDepartment of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; View further author information
,
Nahoko TanakaDepartment of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; View further author information
,
Yoh IshiguroDivision of Clinical Research, Hirosaki National Hospital, National Hospital Organization, Hirosaki, Japan; View further author information
,
Masanori TanakaDepartment of Pathology and Laboratory Medicine, Hirosaki Municipal Hospital, Hirosaki, JapanView further author information
&
Shinsaku FukudaDepartment of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; ;Department of Community Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan; View further author information
 show all
Pages 708-713 | Received 01 Jul 2016, Accepted 11 Feb 2017, Published online: 08 Mar 2017
 
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Abstract

Here we describe a 20-year-old man with ankylosing spondylitis and gut inflammation, who was successfully treated with adalimumab. Capsule endoscopy and ileocolonoscopy showed multiple erosions and aphthoid ulcers in the ileum and the ileocecal valve. Immunohistochemical analysis of the terminal ileum demonstrated that the number of IL-23p19 expressing macrophages was increased. Adalimumab was administered, and his back pain and abdominal symptoms improved. Adalimumab might be an effective treatment for gut inflammation related to ankylosing spondylitis.

Acknowledgements

This report was supported by the Health and Labour Sciences Research Grants for Research on Intractable Diseases from the Ministry of Health, Labour and Welfare, Japan.

Conflict of interest

None.

Additional information

Funding

This report was supported by the Health and Labour Sciences Research Grants for Research on Intractable Diseases from the Ministry of Health, Labour and Welfare, Japan.

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