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Abstract
The pandemic of COVID-19 has caused global social impact and high health risk. Clinical observations have suggested that elevated levels of inflammatory mediators are associated with disease severities in COVID-19 patients, in which the immunological profiles indicate the hyperactivation of innate immune cells and dysregulated adaptive immune responses. The increasing prevalence and disease progression of COVID-19 has emerged as a pressing challenge for the management of rheumatic patients with immune dysregulations. Here we review the immune dysregulations in COVID-19 and discuss the management of COVID-19 patients with rheumatic diseases.
Conflict of interest
None.
Additional information
Funding
This work was supported by grants from the National Natural Science Foundation of China [No. 91842304, 81771761 and 82004171], Chongqing International Institute for Immunology [2020YJC10] and the Fundamental Research Funds for the Central Public Welfare Research Institutes [ZZ13-YQ-033].