Is there evidence to support serum antinuclear antibodies testing in women with recurrent implantation failure undergoing in vitro fertilization?

Abstract

One of the most challenging aspects of reproductive medicine is the management of recurrent implantation failure. Various investigations, including antinuclear antibodies testing, are performed to seek an explanation and guide treatment. However, is there sufficient evidence or available therapeutic options to support antinuclear antibodies testing? We present a short review on the current literature and an attempt at a systematic review evaluating the association between antinuclear antibodies and recurrent implantation failure to address this question.

Keywords:

• In vitro fertilization
• anti-nuclear antibodies
• recurrent implantation failure

Disclosure statement

Y.N., S.A. and N.R.F. declare that they have no conflict of interest.

Ethical approval

Ethical approval was not sought.