ABSTRACT
Background
To evaluate the impact of having first-degree relatives (FDR) with bladder cancer (BC) among non-muscle invasive bladder cancer (NMIBC) patients treated with Bacillus Calmette – Guérin (BCG) on their oncological outcomes.
Methods
The National Phase II BCG/Interferon (IFN) trial database from 125 sites in the U.S.A. (1999–2001) and multi-institutional databases from France (FR) and Lebanon (LB) (2000–2021) were queried for NMIBC patients treated with BCG. Cox regression models were used to evaluate the effect of BC family history on tumor recurrence and progression in their relatives.
Results
There were 867 patients in the U.S.A. cohort and 1232 patients in the FR/LB cohort. Almost 8% of patients in both cohorts had FDR with BC. Patients in the FR/LB cohort were more likely to have carcinoma in situ tumors (CIS) (41% vs. 24%, p < 0.01). Having FDR with BC was not significantly associated with tumor recurrence or progression in the U.S.A. cohort. Conversely, on multivariable analysis FDR history was significantly associated with a 2.10 times increased risk of recurrence (p < 0.01) and a 3.01 times increased risk of progression (p < 0.01) in the FR/LB cohort.
Conclusion
A family history of BC could have an important impact on the response to BCG.
Declaration of interest
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Authors contributions
M. Abou Chakra: Investigation; Conceptualization; Writing – original draft; Methodology; Visualization. M. A. O’Donnell: Conceptualization; Investigation; Methodology; Writing – review &editing; Data curation; Supervision. I. Duquesne: Conceptualization; Investigation; Methodology; Writing – review &editing; Data curation. M. Peyromaure: Conceptualization; Investigation; Methodology; Writing – review &editing; Data curation; Supervision. M. Moussa: Conceptualization; Investigation; Methodology; Writing – review &editing; Data curation; Supervision. S. L. Mott: Conceptualization; Investigation; Methodology; Writing – review &editing; Data curation; Supervision. All authors reviewed and approved this manuscript for publication and agree to be accountable for all aspects of the work.
Reviewer disclosures
Peer reviewers on this manuscript have no relevant financial or other relationships to disclose.