Synthesis of Potential Anti-HIV GP120 Inhibitors Using a Lysine Template

Abstract

Various acylated proteins have been reported in the literature to possess anti-HIV activity. Described here is the preparation of lysine monomers, dimers and trimers acylated with various anhydrides and dioxalanones as simplified mimics of the acylated proteins. Compounds were assayed against HIV-infected C8166 cells and some showed weak anti-HIV activity.

Keywords::

• Gp120 Inhibitors
• Hiv
• Lysine Oligomers
• Acylated Proteins