Synthesis of Aldehydo-sugar Derivatives of Pyrazoloquinoline as Inhibitors of Herpes Simplex Virus Type 1 Replication

Adnan A. Bekhit Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, 21521, Alexandria, Egypt

Ola A. El-Sayed Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, 21521, Alexandria, Egypt

Hassan Y. Aboul-Enein Pharmaceutical Analysis and Drug Development Laboratory, Biological and Medical Research Department (MBC), King Faisal Specialist Hospital and Research Centre, P.O. Box, 11211, Riyadh, Saudi ArabiaCorrespondence[email protected]

Yunus M. Siddiqui Molecular Virology and Infectious Diseases Laboratory, Biological and Medical Research Department (MBC), King Faisal Specialist Hospital and Research Centre, P.O. Box 11211, Riyadh, Saudi Arabia

Mohammed N. Al-Ahdal Molecular Virology and Infectious Diseases Laboratory, Biological and Medical Research Department (MBC), King Faisal Specialist Hospital and Research Centre, P.O. Box 11211, Riyadh, Saudi Arabia

Abstract

Synthesis of a novel series of structurally related pyrazoloquinoline nucleosides is described. All the newly synthesized compounds were examined for their in vitro antiviral activity against herpes simplex type-1 as shown by two different bioassays, namely; crystal violet staining or the MTS tetrazolium dye measurement. The acute toxicity (LD50) values of the biologically active compounds were determined.

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Synthesis of Aldehydo-sugar Derivatives of Pyrazoloquinoline as Inhibitors of Herpes Simplex Virus Type 1 Replication

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Synthesis of Aldehydo-sugar Derivatives of Pyrazoloquinoline as Inhibitors of Herpes Simplex Virus Type 1 Replication

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