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Journal of Enzyme Inhibition and Medicinal Chemistry Volume 19, 2004 - Issue 6
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Research Article

Pharmacomodulation of a Sulfamide 5-HT6 Receptor Ligand

Jacques Renault Faculté des Sciences Biologiques et Médicales, UPRES EA- Institut de Chimie de Rennes, Université de Rennes 1, 2, av. du Pr. Léon Bernard, 35043, Rennes, FranceCorrespondence[email protected]
[email protected]
,
Aurelie Bernard Faculté des Sciences Biologiques et Médicales, UPRES EA- Institut de Chimie de Rennes, Université de Rennes 1, 2, av. du Pr. Léon Bernard, 35043, Rennes, France
,
Solenn Brajeul Faculté des Sciences Biologiques et Médicales, UPRES EA- Institut de Chimie de Rennes, Université de Rennes 1, 2, av. du Pr. Léon Bernard, 35043, Rennes, France
,
Pierre Verhaeghe Faculté des Sciences Biologiques et Médicales, UPRES EA- Institut de Chimie de Rennes, Université de Rennes 1, 2, av. du Pr. Léon Bernard, 35043, Rennes, France
,
Sabrina Butt UPRES EA-Centre d'Etudes et de Recherche sur le Médicament de Normandie, U.F.R. des Sciences Pharmaceutiques, 5, rue Vaubénard, 14032, Caen Cedex, France
,
Frederic Fabis UPRES EA-Centre d'Etudes et de Recherche sur le Médicament de Normandie, U.F.R. des Sciences Pharmaceutiques, 5, rue Vaubénard, 14032, Caen Cedex, France
,
François Dauphin UPRES EA-Centre d'Etudes et de Recherche sur le Médicament de Normandie, U.F.R. des Sciences Pharmaceutiques, 5, rue Vaubénard, 14032, Caen Cedex, France
,
Philippe Uriac Faculté des Sciences Biologiques et Médicales, UPRES EA- Institut de Chimie de Rennes, Université de Rennes 1, 2, av. du Pr. Léon Bernard, 35043, Rennes, France
&
Sylvain Rault UPRES EA-Centre d'Etudes et de Recherche sur le Médicament de Normandie, U.F.R. des Sciences Pharmaceutiques, 5, rue Vaubénard, 14032, Caen Cedex, France
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Pages 577-583 | Received 27 Nov 2003, Accepted 04 Feb 2004, Published online: 03 Oct 2008
 
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Abstract

A series of N-ω-aminoalkyl- or N-ω-amidinoalkyl-2,4,6-triisopropyl benzenesulfonamides has been synthesized and their respective affinity indices on 5-HT6 receptor determined. This evaluation clearly showed that the compounds possessing an arylpiperazine moiety or an amidine function exhibited good affinity for the model.

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