Inhibitory Activity of Cyanidin-3-rutinoside on α-Glucosidase

Sirichai Adisakwattana Department of Pharmacology, Faculty of Veterinary Science, Chulalongkorn University, Pathumwan, Bangkok, 10330, Thailand

Nattaya Ngamrojanavanich Research Center for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand

Kanyarat Kalampakorn Research Center for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand

Wilaiwon Tiravanit Research Center for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand

Sophon Roengsumran Research Center for Bioorganic Chemistry, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, 10330, Thailand

Sirintorn Yibchok-Anun Department of Pharmacology, Faculty of Veterinary Science, Chulalongkorn University, Pathumwan, Bangkok, 10330, ThailandCorrespondence[email protected]

Abstract

Cyanidin-3-rutinoside, a natural anthocyanin, inhibited α-glucosidase from baker's yeast in dose-responsive manner. The IC₅₀ value was 19.7 μM ± 0.24 μM, compared with the IC₅₀ value of voglibose (IC₅₀ = 23.4 ± 0.30 μM). Cyanidin-3-rutinoside was found to be a non-competitive inhibitor for yeast α-glucosidase with a K_i; value in the range of 1.31–1.56 × 10⁻⁵M. These results indicated that cyanidin-3-rutinoside could be classed as a new α-glucosidase inhibitor.

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Inhibitory Activity of Cyanidin-3-rutinoside on α-Glucosidase

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