Synthesis and Antiviral Effect against Herpes Simplex Type 1 of 12-substituted Benzo[c]phenanthridinium Salts

Enguerran Vanquelef Laboratoire SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, 16,Bd Daviers, 49100, Angers, France

Maryvonne Amoros Faculté de Pharmacie, Laboratoire de pharmacognosie et mycologie, 2. av Prof Léon Bernard Rennes cedex, 35043, France

Joel Boustie Faculté de Pharmacie, Laboratoire de pharmacognosie et mycologie, 2. av Prof Léon Bernard Rennes cedex, 35043, France

Michael A. Lynch Faculté de Pharmacie, Laboratoire de pharmacognosie et mycologie, 2. av Prof Léon Bernard Rennes cedex, 35043, France

Roger D. Waigh Department of Pharmaceutical Sciences, Strathclyde Institute for Biomedical Sciences, 27 Taylor Street G4 ONR, Scotland, Glasgow, UK

Olivier Duval Laboratoire SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, 16,Bd Daviers, 49100, Angers, FranceCorrespondence[email protected]
[email protected]

Abstract

The synthesis of benzo[c]phenanthridine alkaloid derivatives is described. In vitro antiviral activity against herpes simplex type 1 (HSV1) has been investigated. Contrary to the natural product fagaronine, which did not have any activity in the HSV1 antiviral tests, four 12-alkoxy derivatives showed good activity demonstrating the importance of the 12-substitution in the structure-activity relationships.

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Synthesis and Antiviral Effect against Herpes Simplex Type 1 of 12-substituted Benzo[c]phenanthridinium Salts

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Synthesis and Antiviral Effect against Herpes Simplex Type 1 of 12-substituted Benzo[c]phenanthridinium Salts

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