Status of some free radical scavenging enzymes in the blood of myocardial infarction patients

Abstract

Pro-oxidant and anti-oxidant systems and their levels have significant roles in occlusive vascular diseases. In the present communication, we have measured the levels of some representative anti-oxidant enzymes in the blood of the patients of myocardial infarction after reperfusion and compared them to age and sex matched healthy persons. Our findings show that the activities of anti-oxidant enzymes (viz. SOD, catalase and glutathione reductase) are significantly decreased whereas there is significant increase in the levels of malonaldialdehyde (a marker of free radical-mediated damage) in the patients. The findings point out that ischemic myocardial disorders are associated with excessive free radical generation and free radical-mediated damage of lipids.

Keywords::

• Free radicals
• anti-oxidant
• blood
• lipid per-oxidation
• myocardial infarction

Acknowledgements

Fellowships from C.S.T., U.P. and grants to the department by DST under FIST program are gratefully acknowledged.