New natural urease inhibitors from Ranunculus repens

Abstract

Phytochemical investigations on the chloroform and ethyl acetate soluble fractions of the roots of Ranunculus repens led to the isolation of methyl 3,4,5-trihydroxybenzoate 1, R(+)- 4-methoxydalbergione 2 and R(+)-dalbergiophenol 3. The structures of these compounds were established through spectral studies including 1D and 2D NMR experiments and by comparison with literature data. These compounds showed potent inhibitory activity against urease.

Keywords::

• Ranunculus repens
• Ranunculaceae
• phenolic constituents
• urease inhibition

Acknowledgements

The authors acknowledge the Higher Education Commission Islamabad, Pakistan for financial support.