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Abstract
Coumarin Schiff-bases (CSB) possessing different substituents on the 4-methyl-2-substituted phenyl imino-2H-chromene-7-ol molecule were evaluated for their in-vitro antioxidant and plausible anti-inflammatory potential. The antioxidant studies of selected CSB were carried out by determining their reducing power, OH√ radical scavenging activity, scavenging of stable 2,2-diphenyl-1-picrylhydrazine (DPPH√) radical and inhibition of the polyphenol oxidase (PPO) enzyme. The assessment of possible anti-inflammatory potential was performed by trypsin inhibition assay and inhibition of β-glucuronidase. All the CSBs under study showed significant reducing effects. The majority of the tested CSB were found to be effective scavengers of DPPH√ radical with moderate to low OH√ scavenging ability and significantly inhibited the activity of PPO. With few exceptions, results from the inhibition assay of trypsin and β-glucuronidase were not encouraging, however they may be helpful in defining structure-activity relationships in further optimization of the lead molecules.
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Acknowledgements
The Authors are thankful to UGC India for financial assistance and HOD, School of Life Sciences, S. R. T. M. University Nanded (MS) for providing the necessary facilities during this work.