Bactericidal activity of different oxovanadium(IV) complexes with Schiff bases and application of chelation theory

Abstract

Oxovanadium(IV) complexes have been synthesized and characterized the general composition [VOL(A)], where H₂L = salicylidene-o-aminothiophenol A¹ = bis(benzylidene)ethylenediamine, A² = bis(acetophenone)ethylenediamine, A³ = 2,2′-bipyridylamine, A⁴ = bis(benzylidene) − 1,8-diaminonaphthalene, A⁵ = thiophene-o-carboxaldeneaniline and A⁶ = thiophene-o-carboxaldene-p-anisidine. Spectral studies indicate that the oxovanadium(IV) complexes assume a six-coordinate octahedral geometry. The antibacterial activities of the complexes against Salmonella typhi, Escherichia coli and Serratia mercescens are higher as compared to the free ligands, vanadyl sulphate, and the control (DMSO) but of moderate activity as compared to the standard drug (tetracycline).

Keywords::

• Oxovanadium(IV) complexes
• Schiff bases
• bactericidal
• tetracycline
• chelation theory
• metal complexes

Acknowledgements

We gratefully acknowledge Prof. R. M. Patel, Head, Department of Chemistry and Prof. M. Dutta, Head, Department of Biosciences, Sardar Patel University, Vallabh Vidyanagar, Gujarat, India for providing the necessary laboratory facilities.