A New Bacillus pasteurii Urease Inhibitor from Euphorbia decipiens

Muhammad Arif Lodhi Dr. Panjwani Center for Molecular Medicine and Drug Research, HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, 75270, Pakistan

Javid Hussain Kohat University of Science and Technology, Kohat, NWFP, Pakistan

Muhammad Athar Abbasi Dr. Panjwani Center for Molecular Medicine and Drug Research, HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, 75270, Pakistan

Amir Reza Jassbi Dr. Panjwani Center for Molecular Medicine and Drug Research, HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, 75270, Pakistan

Muhammad Iqbal Choudhary Dr. Panjwani Center for Molecular Medicine and Drug Research, HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, 75270, Pakistan

Viqar Uddin Ahmad Dr. Panjwani Center for Molecular Medicine and Drug Research, HEJ Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, 75270, Pakistan

Abstract

Inhibition of Bacillus pasteurii urease enzyme by 3,7,15-tri-O-acetyl-5-O-nicotinoyl-13,14-dihydroxymyrsinol (1), a diterpene ester with a myrsinol-type skeleton, isolated from Euphorbia decipiens Boiss. & Buhse, was un-competitive consistent with the molecular docking results. The Ki value was 117.40 ± 0.7 μM.

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A New Bacillus pasteurii Urease Inhibitor from Euphorbia decipiens

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A New Bacillus pasteurii Urease Inhibitor from Euphorbia decipiens

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