Antibacterial Co(II), Ni(II), Cu(II) and Zn(II) Complexes of Schiff bases Derived from Fluorobenzaldehyde and Triazoles

Abstract

Antibacterial Schiff bases derived from 1,2,4-triazoles as well as their metal complexes incorporating cobalt(II), nickel(II), copper(II) and zinc(II) have been synthesized and characterized. Physico-chemical studies suggest that an octahedral geometry for the cobalt(II), nickel(II) and zinc(II)and square-planer geometry for the copper(II) complexes. These complexes have been screened for antibacterial activity against three Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis) and two Gram-negative (Salmonella typhi and Pseudomonas aeruginosa) bacterial strains, and results compared with the activity of the free ligands. The metal complexes were found to be more potent against one or more bacterial strains than the free ligands.

Keywords::

• Antibacterial activity
• Schiff bases
• metal chelates
• 1,2,4-triazoles
• fluorobenzaldehyde

Acknowledgements

This investigation received financial support from the University Grant Commission, New Delhi, No. F.12-47/2003(SR). UGC provided a project fellowship to one of the authors (M.S.B.).

Notes

*This paper was presented at the International Conference on Sustainable Development and Resource Utilization: Current Trends and Perspectives, P-51, 2005, Jaipur.