Adenosine deaminase in ischemia reperfusion injury in patients with myocardial infarction

Abstract

A comparative study on the levels of erythrocyte adenosine deaminase and lipid peroxidation has been undertaken in patients with myocardial infarction before and after thrombolysis along with matched healthy individuals. Our findings show that adenosine deaminase activity is highly elevated in post-reperfused patients when compared to pre- thrombolysed and healthy persons. Malondialdehyde(MDA) levels are also significantly increased in post-thrombolysed patients. The study reveals an important role of adenosine deaminase in reperfusion injury in patients with myocardial infarction.

Keywords::

• Ischemia-reperfusion injury
• adenosine deaminase
• myocardial infarction
• adenosine
• MDA

Acknowledgements

One of us (A K) would like to thank CSIR, New Delhi, for a junior research fellowship. Grants from DST under the FIST program to the Department are gratefully acknowledged.