A new fermentation process allows large-scale production of tetra-N-acetyl-chitotetraosyl allosamizoline

Abstract

A new compound 2, possessing a tetra-N-acetyl-chitotetraosyl moiety as a constituent, was synthesized by bacterial fermentation, which used allosamizoline 1 as the initial acceptor. A 2-binding chitinase assay, indicated that the chitinase was inactivated by 2 with IC₅₀ = 0.03 μg/mL.

Keywords::

• Tetra-N-acetyl-chitotetraosyl allosamizoline
• fermentation
• allosamidin
• chitinase
• inhibition