Synthesis and evaluation of (S)-2-ethoxy-3-phenylpropanoic acid derivatives as insulin-sensitizing agents

Abstract

A series of (S)-2-ethoxy-3-phenylpropanoic acid derivatives were synthesized and their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Compounds 1b and 1d exhibited more potent insulin-sensitizing activity than rosiglitazone.

Keywords::

• (S)-2-ethoxy-3-phenylpropanoic acid derivatives
• type 2 diabetes
• insulin-sensitizing agents

Acknowledgements

We thank the National Natural Science Foundation of China, the Natural Science Foundation of the Hunan and Guizhou Province and the Foundation of Hunan Education Department for financial support.