Template synthesis, spectroscopic studies and biological activities of macrocyclic complexes derived from thiocarbohydrazide and glyoxal

Abstract

A novel series of complexes of the type [M(TML)X₂]; where TML is Tetradentate Macrocyclic Ligand; M = Co(II), Ni(II), Cu(II), Zn(II)or Cd(II); X = Cl⁻ , CH₃COO⁻ or have been synthesized by template condensation of glyoxal and thiocarbohydrazide in the presence of divalent metal salts in methanolic medium. The complexes have been characterized by elemental analyses, conductance measurements, molecular weight determination, magnetic measurements, electronic, NMR, infrared and far infrared spectral studies. Electronic spectra along with magnetic moments suggest a six coordinate octahedral geometry for these complexes. The low molar conductance values indicates them to be non-electrolytes. The biological activities of the metal complexes have been tested in vitro against a number of pathogenic bacteria to assess their inhibitory potential.

Keywords::

• Antibacterial activity
• glyoxal
• divalent metal salts
• thiocarbohydrazide
• metal complexes
• macrocyclic

Acknowledgements

DPS thanks the University Grants Commission, New Delhi for financial support in the form of a Major Research Project (MRP-F.12-62/2003) and RK for the award of a Project Fellow under the above project. Thanks are also due to authorities of N.I.T., Kurukshetra for providing the necessary facilities.

Notes

^†Present address: 212/2, Serum Institute of India Ltd., Hadapsar, Pune-411 028, India.