Synthesis of dimeric phenol derivatives and determination of in vitro antioxidant and radical scavenging activities

Abstract

In this study, di(2,6-dimethylphenol) (Di-DMP), di(2,6-diisopropylphenol) (Di-DIP, dipropofol) and di(2,6-di-t-butylphenol) (Di-DTP) were synthesized by the reaction of monomeric phenol derivatives with catalytic CuCl(OH). TMEDA and Na₂S₂O₄. Their antioxidant capacity and radical scavenging activity were examined using different in vitro methodologies such as 1,1-diphenyl-2-picryl-hydrazyl (DPPH·) free radical scavenging, 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging activity, total antioxidant activity by ferric thiocyanate, total reducing power by potassium ferricyanide reduction method, superoxide anion radical scavenging, hydrogen peroxide scavenging and ferrous ions chelating activities.

Keywords::

• Propofol
• monophenol
• diphenol
• antioxidant activity
• dimeric form
• radical scavenging

Acknowledgements

This study was partially supported by Atatürk University Research Foundation (Project no: 2001/35). The authors are grateful to the Research Fund of Atatürk University for financial support.