Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines

R. Ramajayam Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M.S University of Baroda, Vadodara, 390 001, India

Rajani Giridhar Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M.S University of Baroda, Vadodara, 390 001, India

Mange Ram Yadav Pharmacy Department, Faculty of Technology and Engineering, Kalabhavan, The M.S University of Baroda, Vadodara, 390 001, India

Hakim Djaballah HTS Core Facility, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 487, New York, NY, 10583, USA

David Shum HTS Core Facility, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 487, New York, NY, 10583, USA

Constantin Radu HTS Core Facility, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 487, New York, NY, 10583, USA

Abstract

Novel substituted 5,7-diaryl-2,3-dihydro-1,4-diazepines and 4,6-diaryl-2-aminopyrimidines were synthesized and tested for their antiproliferative activity. Title compounds were obtained by cyclocondensation of a substituted flavone with ethylenediamine and guanidine respectively. The cytotoxicity in vitro against various human leukemic cancer cell lines viz., Jurkat, HL60, MOLT3, NCEB-1, K562 was determined.

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Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines

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Synthesis and antiproliferative activity of some diaryldiazepines and diarylpyrimidines

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