Structure and biological properties of first row d-transition metal complexes with N-substituted sulfonamides

Abstract

Cobalt (II), copper (II), nickel (II) and zinc (II) complexes with 2-hydroxy-1-naphthaldehyde derived N-substituted sulfonamides have been synthesized and the nature of bonding and structure of compounds have been deduced from physical, analytical and spectral (IR, ¹H NMR, ¹³C NMR, Mass and electronic) data. An octahedral geometry has been suggested for the complexes. Complexes along with the ligands were assessed for their antibacterial and antifungal activities on different species of pathogenic bacteria and fungi. The results revealed the ligands to possess moderate to significant antibacterial activity which was, in many cases, enhanced on chelation. Similar results were observed for antifungal activity. Brine shrimp bioassay was also carried out for in vitro cytotoxic properties against Artemia salina.

Keywords::

• Sulfonamides
• metal (II) complexes
• antibacterial
• antifungal
• cytotoxicity

Acknowledgements

We are thankful to the Higher Education Commission (HEC), Government of Pakistan for the financial assistance to carry out research Project No. 20-16/Acad(R&D)/2^nd Phase/03/211. We are also grateful to HEJ research Institute of Chemistry, University of Karachi for the help in undertaking NMR, mass spectra and biological assay.