Synthesis of new bisaryl cyclopentathiophene and thieno-cyclopentoxazolidine derivatives as potential cytotoxic agents

Abstract

The synthesis of new bisaryl thienocyclopentoxazolidine derivatives was achieved through a Suzuki cross-coupling procedure with the aim to enhance the previously reported cytotoxicity of the series. The biological activity, evaluated in the NCI's in vitro human disease-oriented tumor cell line screening panel, was however partially conserved by the pharmacomodulations.

Keywords::

• Thiophene
• cyclopentane
• oxazolidine
• Suzuki cross-coupling
• cytotoxicity