Synthesis and PC3 androgen-independent prostate cells antiproliferative effect of fagaronine derivatives

Enguerran Vanquelef Univ Angers, SONAS, UFR Sciences Pharmaceutiques et Ingénierie de la Santé, Angers, F-49100, France

Jean-Jacques Hélesbeux Univ Angers, SONAS, UFR Sciences Pharmaceutiques et Ingénierie de la Santé, Angers, F-49100, France

Olivier Duval Univ Angers, SONAS, UFR Sciences Pharmaceutiques et Ingénierie de la Santé, Angers, F-49100, France

Eric Debiton Centre Jean Perrin, Clermont-Ferrand, F-63005, France, 63005, France, Clermont-Ferrand, 63005, France

Chantal Barthomeuf Centre Jean Perrin, Clermont-Ferrand, F-63005, France, 63005, France, Clermont-Ferrand, 63005, France

Christian Jarry Univ Bordeaux 2, U.F.R. Pharmacie, EA 2962 Pharmacochimie, Bordeaux, F -33076, France

Isabelle Forfar Univ Bordeaux 2, U.F.R. Pharmacie, EA 2962 Pharmacochimie, Bordeaux, F -33076, France

Pascal Richomme Univ Angers, SONAS, UFR Sciences Pharmaceutiques et Ingénierie de la Santé, Angers, F-49100, France

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Abstract

Fagaronine derivatives syntheses were optimized and their effect on PC3 androgen-independent prostate cell line was evaluated. An assessment of the lipophilicity of the benzo[c]phenanthridine derivatives was achieved at pH 7.4 and et 6.7 by determining log D.

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Synthesis and PC3 androgen-independent prostate cells antiproliferative effect of fagaronine derivatives

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Synthesis and PC3 androgen-independent prostate cells antiproliferative effect of fagaronine derivatives

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