The convenient synthesis and evaluation of the anticancer activities of new resveratrol derivatives

Abstract

In the present study we report the simple synthesis and antitumour activity of novel stilbene derivatives 13–22. The key synthetic strategies involved Wadsworth-Horner-Emmons condensation and coupling reactions in high yields. All compounds showed significant growth inhibition on human tumour cell lines, with the most potent compound (19) exhibiting an IC₅₀ of 5.7 μM – 11.4 μM in vitro.

Keywords::

• Stilbene derivatives
• Wadsworth-Horner-Emmons reaction
• anticancer activity

Acknowledgements

This work has been supported by a KOSEF Brain Neurobiology Grant (2007), Ewha Global Challenge (BK21) grant, a research grant from the Ministry of Health & Welfare (Project No B040002), the Republic of Korea, E. L and Y. L the fellowship of the BK 21 program from the Ministry of Education and Human Resources Development and the Seoul Science Fellowship Program, and a grant (20070301-034-026-007-04-00) from BioGreen 21 Program, Rural Development Administration, Republic of Korea. Hyung-In Moon and Ill-Min Chung equally contributed to this work.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.