In vitro anti-leishmanial activities of germatranyl and Silicon incorporated diorganotin derivatives: Synthesis and spectroscopic properties

Abstract

A series of germanium and silicon incorporated diorganotin derivatives of general formula where R¹ = H₃C, C₆H₅, p-CH₃C₆H₄, p-FC₆H₄; R² = H₂CSi(CH₃)₂C₆H₅, H₂CC₆H₅, p-CH₃C₇H₇ were synthesized by the reaction of appropriate diorganotin dichlorides and germatranyl (substituted) propionic acid in 1:2 mole ratio, respectively. The evidence regarding their structure is mainly based on spectroscopic data obtained by multinuclear (¹H, ¹³C, ²⁹Si, ¹¹⁹Sn) NMR and ^119mSn Mössbauer, IR and mass spectral studies in combination with melting points and elemental analyses. The compounds have been screened for in vitro anti-leishmanial activity against promastigotes of Leishmania major and the results offer potent activities which are better than the standard drug, pentamidine, for one compound.

• Germatrane
• Silicon
• Diorganotin
• Spectroscopy
• Antileishmanial activity

Acknowledgements

U.S. is thankful to MoST. Govt. of Pakistan for the award of S & T Scholarship and Dr. Imtiaz-ud-Din is grateful to the Punjab Education Department for the grant of study leave for doing post-doctoral research.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.