![Sample our Bioscience journals, sign in here to start your access, Latest two full volumes FREE to you for 14 days]({"type":"image" , "src" : "/sda/5925/TOC-Subject-Sample-2021-Bioscience.jpg"})
Abstract
Three series of sintenin derivatives (compounds 1–14) were designed and prepared and their antioxidative and neuroprotective effects were evaluated. The in vitro models of scavenging 1,1-diphenyl-2-picrylhydrazyl (DPPH) radicals, chelating ferrous ions, inhibiting the rat brain homogenates lipid peroxidation, and protecting neurons damaged by hydrogen peroxide were employed for bioassays. It was found that sintenin derivatives 4 and 13 showed remarkable antioxidative and neuroprotective activities.
Acknowledgements
This work was partially supported by intramural foundation from Zhejiang University. We thank the Zhejiang Hisun Group for instrumental assistances. One of the authors (Y. Zhao) is grateful to Chinese Ministry of Education and Mr. Ka-Ching Lee for the award of a “Cheung Kong Scholars Professorship”. The authors acknowledge helpful discussions with Prof. H.K. Cheng at Chinese University of Hong Kong.
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.