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Abstract
A series of nine polypyridyl-ruthenium (II) complexes (N-ligands = 2,2′-bipyridines; 2,2′-6′,2′-terpyridines, di-alkyloxy-2,2′-6,2-bipyridine-3,3′-di-carboxylates), were tested against Mycobacterium tuberculosis (MBT). The complex (11) showed remarkable activity against MBT as compared to other complexes, (1–10). The aquo ligand of complex (11), as opposed to other chloro and acetonitrile derivatives, appears to play a key role in the antitubercular potency of this new class of metal-based compounds.
Acknowledgements
This work was supported by grants from the Ministry of Education of Morocco (PGR-UMP-BH-2005 and CUD-UMP-BH-2007). We are indebted to Professor P.H. Dixneuf and Dr. H. Le Bozec of Rennes1 for sending us samples of some complexes and we thank the Tuberculosis Antimicrobial Acquisition and Coordinating Facility (TAACF) of United States for biological tests.
Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.