Synthesis of a novel class of some 1,3,4-oxadiazole derivatives as antimicrobial agents

Abstract

In an effort to discover new candidates with improved antimicrobial activities we report here the synthesis and in vitro biological evaluation of various series of 2-{(3,4,5-trimethoxy phenyl-1,3,4-oxadiazolyl)-5-thio}-4-(morpholino)-6-(phenyl ureido)-s-triazine (7a-i) and 2-{(3,4,5-trimethoxy phenyl-1,3,4-oxadiazolyl)-5-thio}-4-(morpholino)-6-(phenyl thioureido)-s-triazine (8a-g). Antimicrobial properties of the title compounds were investigated against two Gram ( + ve) bacteria (S. aureus, B. subtilis), two Gram ( − ve) bacteria (P. aeruginosa, E. coli) and yeast-like fungi (C. albicans) using the broth microdilution method.

Keywords::

• 1, 3, 4-oxadiazole
• s-triazine
• thiourea
• urea
• antimicrobial activity

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.