A facile solid-state synthesis and in vitro antimicrobial activities of some 2,6-diarylpiperidin/tetrahydrothiopyran and tetrahydropyran-4-one oximes

Abstract

Some 2,6-diarylpiperidin/tetrahydrothiopyran/tetrahydropyran-4-one oximes were synthesized in dry media under microwave irradiation and were evaluated for their in vitro antibacterial activity against clinically isolated bacterial strains i.e. S.aureus, β-H.Streptococcus, E.coli, P.aeruginosa, S.typhii and in vitro antifungal activities against fungal strains i.e. C.albicans, Rhizopus, A.niger and A.flavus. Structure-activity relationships for the synthesized compounds showed that compounds 12 and 15 exerted excellent antibacterial activity against all the tested bacterial strains except 15 against S.aureus and β-H.streptococcus. Against C.albicans and A.flavus, compound 15 exerted potent antifungal activities while against Rhizopus, compound 16 showed promising activity.

Keywords::

• 2,6-diarylpiperidin-4-one oximes
• 2,6-diaryltetrahydrothiopyran-4-one oximes
• 2,6-diaryltetrahydropyran-4-one oximes
• antibacterial activity
• antifungal activity

Acknowledgements

Authors are thankful to NMR Research Centre, Indian Institute of Science, Bangalore for recording the spectra. Two of our authors namely J.Thanusu and V.Kanagarajan are highly thankful for Annamalai University authorities for providing financial support in the form of Research Fellowship.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

M. Gopalakrishnan, J. Thanusu, & V. Kanagarajan

A facile solid-state synthesis and in vitro antimicrobial activities of some 2,6-diarylpiperidin/tetrahydrothiopyran and tetrahydropyran-4-one oximes

669–675