Calpain inhibitory flavonoids isolated from Orostachys japonicus

Abstract

The n-butanol (n-BuOH) fraction of Orostachys japonicus A. Berger (Crassulaceae) significantly inhibited calpain activity. Through the activity-guided isolation from the n-BuOH fraction, herbacetin 8-O-α-D-ribopyranoside (1), kaempferol (2), quercetin (3), afzelin (4), astragalin (5), isoquercetin (6) and quercitrin (7) were obtained. Their structures were determined by spectroscopic techniques. Among them, compound 3 and 5 had significant calpain inhibitory activities.

Keywords::

• Orostachys japonicus
• flavonoid
• calpain
• neuroprotection
• inhibition

Acknowledgements

This work was supported by Research Settlement Fund for the new faculty of SNU.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.