Biologically active macrocyclic complexes derived from diaminonaphthalene and glyoxal: Template synthesis and spectroscopic approach

Abstract

A novel series of complexes of the type [M(C₂₄H₁₆N₄)X₂]; where M = Co(II), Ni(II), Cu(II), Zn(II) and Cd(II); X = Cl^{− 1}, , CH₃COO^{− 1} has been synthesized by template condensation of 1,8-diaminonaphthalene and glyoxal in the presence of divalent metal salts in methanolic medium. The complexes have been characterized with the help of elemental analyses, conductance measurements, molecular weight determination, magnetic measurements, electronic, NMR, infrared and far infrared spectral studies. The low value of molar conductance indicates them to be non-electrolytes. On the basis of various studies a distorted octahedral geometry may be proposed for all of these complexes. These metal complexes were also tested for their in vitro antibacterial and antifungal activities to assess their inhibiting potential.

Keywords::

• Biological activity
• diaminonaphthalene
• macrocyclic complexes
• metal coordinate
• spectroscopic studies

Acknowledgements

D.P. Singh thanks the University Grants Commission, New Delhi for financial support in the form of Major Research Project [MRP-F.No. 32-196/2006(SR)] and Krishan Kumar for the award of Project Fellowship under the above project. Thanks are also due to authorities of N.I.T., Kurukshetra for providing necessary research facilities.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.