Antibacterial activity and spectral studies of trivalent chromium, manganese, iron macrocyclic complexes derived from oxalyldihydrazide and glyoxal

Abstract

A new series of complexes is synthesized by template condensation of oxalyldihydrazide and glyoxal in methanolic medium in the presence of trivalent chromium, manganese and iron salts forming complexes of the type: [M(C₈H₈N₈O₄)X]X₂ where M = Cr(III), Mn(III), Fe(III) and X = Cl^{− 1}, , CH₃COO^{− 1}. The complexes have been characterized with the help of elemental analyses, conductance measurements, magnetic susceptibility measurements, electronic, NMR, infrared and far infrared spectral studies. On the basis of these studies, a five coordinate square pyramidal geometry for these complexes has been proposed. The biological activities of the metal complexes were tested in vitro against a number of pathogenic bacteria and some of the complexes exhibited remarkable antibacterial activities.

Keywords::

• Antibacterial activity
• macrocyclic complexes
• infrared spectra
• magnetic measurements
• metal complexes

Acknowledgements

D.P. Singh thanks the University Grants Commission, New Delhi for financial support in the form of Major Research Project (MRP-F.12-62/2003) and Ramesh Kumar for the award of Project Fellowship under the above project. Thanks are also due to authorities of N.I.T., Kurukshetra for providing necessary research facilities.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.