Antioxidant phenylpropanoid glycosides from Buddleja davidii

Abstract

Phytochemical investigations on the n-BuOH-soluble fraction of the whole plant of Buddleja davidii led to the isolation of the phenylpropanoid glycosides 1-10. Their structures were determined by 1D and 2D NMR spectroscopic techniques. All the compounds showed potent antioxidative activity in three different tests, with IC₅₀ values in the range 4.15-9.47 μM in the hydroxyl radical (˙OH) inhibitory activity test, 40.32-81.15 μM in the total ROS (reactive oxygen species) inhibitory activity test, and 2.26-7.79 μM in the peroxynitrite (ONOO⁻) scavenging activity test. Calceolarioside A (1) displayed the strongest scavenging potential with IC₅₀ values of (4.15 ± 0.07, 40.32 ±  0.09, 2.26 ± 0.03μM) for ˙OH, total ROS and scavenging of ONOO⁻, respectively.

Keywords::

• Buddleja davidii
• Buddlejaceae
• phenylpropanoid glycosides
• antioxidant
• Buddleia

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.