Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium

Francesca MargheriDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy,

Mariangela CerusoNeurofarba Department, University of Florence, Florence, Italy,

Fabrizio CartaNeurofarba Department, University of Florence, Florence, Italy,

Anna LaurenzanaDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy,

Laura MaggiDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy, and

Simone LazzeriAnna Meyer Children's Hospital and University of Florence, Florence, Italy

Gabriele SimoniniNeurofarba Department, University of Florence, Florence, Italy, ;Anna Meyer Children's Hospital and University of Florence, Florence, Italy

Francesco AnnunziatoDepartment of Experimental and Clinical Medicine, University of Florence, Florence, Italy, and

Mario Del RossoDepartment of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy,

Claudiu T. SupuranNeurofarba Department, University of Florence, Florence, Italy, Correspondence[email protected]

Rolando CimazNeurofarba Department, University of Florence, Florence, Italy, ;Anna Meyer Children's Hospital and University of Florence, Florence, ItalyCorrespondence[email protected]

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Abstract

Juvenile idiopathic arthritis (JIA) is the most common form of chronic rheumatic disease affecting children worldwide, with some features similar to adult rheumatoid arthritis (RA). In the present study, we aim at investigating novel markers that will allow in the future for tailored, more personalized treatment strategies. Hence, taking notice of several reports proving the role of local acidosis as a causal link between inflammatory diseases and related pain, and the involvement of several carbonic anhydrases (CA, EC 4.2.1.1) isoforms in articular diseases, we evaluated in JIA patients the expression of these metalloenzymes. We identified that JIA patients show high levels of active CA IX and XII isoforms. Our results represent the first evidence of the identification of these enzymes as potential therapeutic targets and development of novel innovative therapies for arthritis, also considering that the two isoforms are validated antitumor targets.

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Declaration of interest

The authors state no conflict of interest.

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Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium

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Overexpression of the transmembrane carbonic anhydrase isoforms IX and XII in the inflamed synovium

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