Design, synthesis and evaluation of 3-quinoline carboxylic acids as new inhibitors of protein kinase CK2

Abstract

In this article, the derivatives of 3-quinoline carboxylic acid were studied as inhibitors of protein kinase CK2. Forty-three new compounds were synthesized. Among them 22 compounds inhibiting CK2 with IC₅₀ in the range from 0.65 to 18.2 μM were identified. The most active inhibitors were found among tetrazolo-quinoline-4-carboxylic acid and 2-aminoquinoline-3-carboxylic acid derivatives.

Keywords:

• Inhibitor
• protein kinase CK2
• tetrazolo[1,5-a]quinoline-4-carboxylic acid
• 2-aminoquinoline-3-carboxylic acid
• 2-chloroquinoline-3-carboxylic acid
• 2-oxo-1,2-dihydroquinoline-3-carboxylic acid
• 5-oxo-2,3-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-6-carboxylic acid

Acknowledgements

We thank Otava Ltd. Company for material and finance support.

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.