Antimicrobial metal-based thiophene derived compounds

Abstract

A novel series of thiophene derived Schiff bases and their transition metal- [Co(II), Cu(II), Zn(II), Ni(II)] based compounds are reported. The Schiff bases act as tridentate ligands toward metal ions via azomethine-N, deprotonated-N of ammine substituents and S-atom of thienyl moiety. The synthesized ligands along with their metal complexes were screened for their in vitro antibacterial activity against six bacterial pathogens (Escherichia coli, Shigella flexneri, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and Bacillus subtilis) and for antifungal activity against six fungal pathogens (Trichophytonlongifusus, Candida albicans, Aspergillus flavus, Microsporum canis, Fusarium solani and Candida glabrata). The results of antimicrobial studies revealed the free ligands to possess potential activity which significantly increased upon chelation.

Keywords:

• Acetyl thiophene
• antimicrobial activity
• diammines
• metal(II) chelates
• tridentate ligands

Acknowledgments

The authors are also grateful to HEJ research Institute of Chemistry, University of Karachi, Pakistan, for providing their help in taking NMR, mass spectra and for the help in carrying out antibacterial and antifungal studies.

Disclosure statement

The authors declare that there is no conflict of interests regarding the publication of this article and are responsible for the contents and writing of the article.