Microwave-assisted synthesis and bioevaluation of new sulfonamides

Abstract

In this study, 4-[5-(4-hydroxyphenyl)-3-aryl-4,5-dihydro-1H-pyrazol-1-yl]benzenesulfonamide derivatives (8-14) were synthesized for the first time by microwave irradiation and their chemical structures were confirmed by ¹H NMR, ¹³C NMR and HRMS. Cytotoxic activities and inhibitory effects on carbonic anhydrase I and II isoenzymes of the compounds were investigated. The compounds 9 (PSE = 4.2), 12 (PSE = 4.1) and 13 (PSE = 3.9) with the highest potency selectivity expression (PSE) values in cytotoxicity experiments and the compounds 13 (Ki = 3.73 ± 0.91 nM toward hCA I) and 14 (Ki = 3.85 ± 0.57 nM toward hCA II) with the lowest Ki values in CA inhibition studies can be considered as leader compounds for further studies.

Keywords:

• Carbonic anhydrase
• cytotoxicity
• microwave
• pyrazoline
• sulfonamide

Disclosure statement

The authors report no conflict of interest and are responsible for the contents and writing of the paper.

Funding

This study was supported by the Research Foundation of Ataturk University, Turkey. Project Number is 2012/74.