Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity

Abstract

Twenty-three novel resveratrol-based cinnamic ester hybrids were designed and synthesized. All the compounds were evaluated for their anti-inflammatory activity using RAW264.7 cells. Among them, compound D15 was found to be the most potent one in inhibiting NO production in LPS-stimulated RAW264.7 cells. The further study indicated that compound D15 could suppress expression of proteins iNOS, COX-2, p-p65, and p-IκB LPS-induced. Immunofluorescence further revealed compound D15 could reduce activation p65 in nuclei. All the results indicated that the anti-inflammatory activity of title compound may partly due to its inhibitory effect on the NF-κB signaling pathway.

Keywords:

• Resveratrol derivatives
• cinnamic ester
• anti-inflammatory
• NF-κB signaling pathway
• molecular docking

Additional information

Funding

We gratefully acknowledge financial support from the National Natural Science Foundation of China (21602042, 21572003), Anhui Provincial Natural Science Foundation (1508085MB33), the Fundamental Research Funds for the Central Universities, and the Key Scientific and Technological Project of Anhui Provincial Tobacco Company (No. 20150551007).