Antibacterial action mechanisms and mode of trypsin inhibitors: a systematic review

Abstract

This systematic review (SR) aimed to gather studies describing the antibacterial action mechanisms and mode of trypsin inhibitors. The review protocol was registered (PROSPERO: CRD42020189069). Original articles resulting from studies in animal models, in bacterial culture, and using cells that describe antibacterial action of trypsin inhibitor-type peptides or proteins were selected in PubMed, Science Direct, Scopus, Web of Science, BVS, and EMBASE. The methodological quality assessment was performed using the PRISMA and OHAT tool. 2382 articles were retrieved, 17 of which were eligible. Four studies demonstrated the action mechanism directly on the bacterial membrane, and the fifth study on endogenous proteases extracted from the bacteria themselves. The antibacterial action mode was presented in the other studies, which can generate bacteriostatic or bactericidal effects without describing the mechanisms. This study generated information to enable new preclinical or clinical studies with molecules contributing to public health.

Keywords:

• Antimicrobial peptides
• bioactive proteins
• infectious diseases
• bacteria

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported for scholarship and payment of fees by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Finance Code 001 - CAPES), the Conselho Nacional de Desenvolvimento Cientítico e Tecnológico (Award Number: 426116/2018–6 - CNPq) research promotion agencies.